Protein Details: ATP-sensitive inward rectifier potassium channel 1

Protein ID

ICDB_Pro_0544

Protein Name

ATP-sensitive inward rectifier potassium channel 1

Gene Name

KCNJ1; ROMK1

Organism

Homo sapiens (Human)

Length

391 amino acids

AlphaFoldDB

AF-P48048-F1-model_v4.pdb

Function

In the kidney;probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium

Sequence

MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

223..230

Disease

Bartter Syndrome;Type 2;Antenatal and Bartter Disease

Location

In the kidney and pancreatic islets. Lower levels in skeletal muscle; pancreas; spleen; brain; heart and liver.

DOI ID

10.1016/s0021-9258(19)51076-6; 10.1016/s0378-1119(96)00759-7; 10.1101/gr.2596504; 10.1007/bf00207372; 10.1074/jbc.m005338200; 10.1016/j.bbrc.2003.10.037; 10.1074/jbc.m212301200; 10.1113/jphysiol.2005.102202; 10.1038/ng1096-152; 10.1093/hmg/6.1.17; 10.1074/jbc.273.37.23884; 10.1126/science.1133427

RefSeq

NP_000211.1 [P48048-1]; NP_722448.1 [P48048-2]; NP_722449.3 [P48048-3]; NP_722450.1 [P48048-2]; NP_722451.1 [P48048-2]